Longvida® Optimized Curcumin® Extract (from Curcuma longa Root)

COMMON NAME

Turmeric | Curcumin 

TOP BENEFITS OF LONGVIDA^®

Supports cognitive function *

Supports exercise recovery *

Supports healthy vision *

WHAT IS LONGVIDA^®?

Longvida^® was developed by university neuroscientists to overcome issues with the low bioavailability of curcumin [1] and is trademarked as “the Cognitive Curcumin of Choice^®” and as “Longvida Optimized Curcumin^®.” Curcumin comes from turmeric (Curcuma longa rhizome, a plant from the ginger family), is the pigment that gives turmeric its characteristic yellow-orange color, and is why turmeric is sometimes referred to as “yellow root” or “golden spice.” Turmeric is widely used as a food spice, especially in South Asia, and has been used in Ayurveda traditional medicine for thousands of years. Longvida® has been clinically studied to support a number of health applications, including, but not limited to, cognitive health, retinal health, vascular health, exercise recovery, sports nutrition, joint health, healthy aging, immune health, and adaptogenic properties.* 

NEUROHACKER’S LONGVIDA^® SOURCING

Longvida^® is a patented turmeric extract standardized to deliver free curcumin to target tissues, including the brain.*

Longvida^® has been used in human clinical studies. It has been a finalist and winner of several awards for outstanding research initiatives. 

Longvida^®️ and Optimized Curcumin^®️ are registered trademarks of Verdure Sciences, Inc. Patents: www.vs-corp.com/ip.html

Longvida^® is non-GMO, gluten-free, and vegan.

LONGVIDA^® FORMULATING PRINCIPLES AND RATIONALE

In human studies, the dose of Longvida^® has ranged from 400 mg to 2000 mg/day [2–5], with cognitive studies emphasizing a 400 mg serving, while joint health and exercise recovery have used 800 mg. Our recommended serving was selected to be within the studied range, taking into consideration any complementary features of other ingredients in the formulation and the intended benefits and use of the formula. 

CURCUMIN KEY MECHANISMS

Supports brain function*

Supports working memory (in older individuals)* [2,3]

Supports memory* [6]

Supports attention* [2,6]

Supports cognitive function (in animals)* [7–16]

Supports neuroprotective functions* [6,17,18]

Supports antioxidant defenses and counters oxidative stress* [7,9,10,15,19,20]

Supports dendritic spine density and dendritic length* [12]

Supports brain-derived neurotrophic factor (BDNF) signaling* [15]

Supports long-term potentiation (LTP)* [21]

Supports brain NF-κB and immune signaling* [9,22–24]

Supports neural mitophagy and mitochondrial function* [25,26]

Supports neuronal autophagy* [27–29]

Counters age-related changes in clock gene rhythms in the SCN* [30]

Supports a healthy mood *

Supports positive affect* [31–33]

Supports calm and relaxed mood* [2,32]

Supports visual health* 

Supports visual function* [34–37]

Supports healthy retinal function* [35,37–40]

Supports blue light defenses* [38]

Supports ocular antioxidant defenses and couters oxidative stress* [39,41]

Supports healthy retinal vasculature and blood flow* [34,42]

Supports gut health*

Supports gut microbiota* [43–48]

Influences gut microbiota metabolism* [49]

Supports intestinal barrier function* [47,50]

Promotes healthy aging and longevity*

Supports healthy vascular function* [4,5]

Supports anti-senescence mechanisms* [51–53]

Supports the management of senescent cells* [54,55]

Supports cellular functions involved with pruning stressed cells* [56–64]

Supports autophagy* [52]

Supports stem cell proliferation* [53]

Supports cellular signaling* 

Influences PI3K/AKT signaling* [58]

Influences NF-κB signaling* [17,54,62,63,65]

Influences Nrf2 signaling* [54]

Complementary ingredients*

Quercetin for supporting cellular and tissue health* [66–71]

Luteolin for supporting endothelial function* [72]

Silymarin and silibinin (from milk thistle extracts) for supporting cellular and tissue health* [73–79]

Resveratrol in supporting the management of senescent cells* [80]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]V.S. Gota, G.B. Maru, T.G. Soni, T.R. Gandhi, N. Kochar, M.G. Agarwal, J. Agric. Food Chem. 58 (2010) 2095–2099.

[2]K.H.M. Cox, A. Pipingas, A.B. Scholey, J. Psychopharmacol. 29 (2015) 642–651.

[3]K.H.M. Cox, D.J. White, A. Pipingas, K. Poorun, A. Scholey, Nutrients 12 (2020).

[4]J.R. Santos-Parker, T.R. Strahler, C.J. Bassett, N.Z. Bispham, M.B. Chonchol, D.R. Seals, Aging 9 (2017) 187–208.

[5]Gerontologist 55 (2015) 195–195.

[6]G.W. Small, P. Siddarth, Z. Li, K.J. Miller, L. Ercoli, N.D. Emerson, J. Martinez, K.-P. Wong, J. Liu, D.A. Merrill, S.T. Chen, S.M. Henning, N. Satyamurthy, S.-C. Huang, D. Heber, J.R. Barrio, Am. J. Geriatr. Psychiatry 26 (2018) 266–277.

[7]M. Belviranlı, N. Okudan, K.E.N. Atalık, M. Öz, Biogerontology 14 (2013) 187–196.

[8]S. Dong, Q. Zeng, E.S. Mitchell, J. Xiu, Y. Duan, C. Li, J.K. Tiwari, Y. Hu, X. Cao, Z. Zhao, PLoS One 7 (2012) e31211.

[9]M.R. Sarker, S. Franks, N. Sumien, N. Thangthaeng, F. Filipetto, M. Forster, PLoS One 10 (2015) e0140431.

[10]C.Y. Sun, S.S. Qi, P. Zhou, H.R. Cui, S.X. Chen, K.Y. Dai, M.L. Tang, Pharmacol. Biochem. Behav. 105 (2013) 76–82.

[11]S.Y. Yu, M. Zhang, J. Luo, L. Zhang, Y. Shao, G. Li, Prog. Neuropsychopharmacol. Biol. Psychiatry 45 (2013) 47–53.

[12]B. Vidal, R.A. Vázquez-Roque, D. Gnecco, R.G. Enríquez, B. Floran, A. Díaz, G. Flores, Synapse 71 (2017).

[13]A. Kumar, A. Prakash, S. Dogra, J. Asian Nat. Prod. Res. 13 (2011) 42–55.

[14]L. Conboy, A.G. Foley, N.M. O’Boyle, M. Lawlor, H.C. Gallagher, K.J. Murphy, C.M. Regan, Biochem. Pharmacol. 77 (2009) 1254–1265.

[15]X. Wu, H. Chen, C. Huang, X. Gu, J. Wang, D. Xu, X. Yu, C. Shuai, L. Chen, S. Li, Y. Xu, T. Gao, M. Ye, W. Su, H. Liu, J. Zhang, C. Wang, J. Chen, Q. Wang, W. Cui, Metab. Brain Dis. 32 (2017) 789–798.

[16]T.L. Moore, B. Bowley, P. Shultz, S. Calderazzo, E. Shobin, R.J. Killiany, D.L. Rosene, M.B. Moss, Geroscience 39 (2017) 571–584.

[17]Q. Qiao, Y. Jiang, G. Li, Anticancer Drugs 23 (2012) 597–605.

[18]Q.-L. Ma, X. Zuo, F. Yang, O.J. Ubeda, D.J. Gant, M. Alaverdyan, E. Teng, S. Hu, P.-P. Chen, P. Maiti, B. Teter, G.M. Cole, S.A. Frautschy, J. Biol. Chem. 288 (2013) 4056–4065.

[19]K. Bala, B.C. Tripathy, D. Sharma, Biogerontology 7 (2006) 81–89.

[20]M. Ashrafizadeh, Z. Ahmadi, R. Mohammadinejad, T. Farkhondeh, S. Samarghandian, Curr. Mol. Med. 20 (2020) 116–133.

[21]Y.-F. Cheng, L. Guo, Y.-S. Xie, Y.-S. Liu, J. Zhang, Q.-W. Wu, J.-M. Li, Neurochem. Res. 38 (2013) 98–107.

[22]M. Shailaja, K.M. Damodara Gowda, K. Vishakh, N. Suchetha Kumari, J. Natl. Med. Assoc. 109 (2017) 9–13.

[23]W. Li, N.C. Suwanwela, S. Patumraj, Microvasc. Res. 106 (2016) 117–127.

[24]H.-T. Zhu, C. Bian, J.-C. Yuan, W.-H. Chu, X. Xiang, F. Chen, C.-S. Wang, H. Feng, J.-K. Lin, J. Neuroinflammation 11 (2014) 59.

[25]W. Wang, J. Xu, Curr. Neurovasc. Res. 17 (2020) 113–122.

[26]G.P. Eckert, C. Schiborr, S. Hagl, R. Abdel-Kader, W.E. Müller, G. Rimbach, J. Frank, Neurochem. Int. 62 (2013) 595–602.

[27]L.-T. Yi, S.-Q. Dong, S.-S. Wang, M. Chen, C.-F. Li, D. Geng, J.-X. Zhu, Q. Liu, J. Cheng, Neurobiol. Dis. 136 (2020) 104715.

[28]C. Wang, X. Zhang, Z. Teng, T. Zhang, Y. Li, Eur. J. Pharmacol. 740 (2014) 312–320.

[29]J. Wang, Y. Liu, X.-H. Li, X.-C. Zeng, J. Li, J. Zhou, B. Xiao, K. Hu, Can. J. Physiol. Pharmacol. 95 (2017) 501–509.

[30]K. Kukkemane, A. Jagota, Biogerontology 20 (2019) 405–419.

[31]B. Kanchanatawan, S. Tangwongchai, A. Sughondhabhirom, S. Suppapitiporn, S. Hemrunrojn, A.F. Carvalho, M. Maes, Neurotox. Res. 33 (2018) 621–633.

[32]S. Asadi, M.S. Gholami, F. Siassi, M. Qorbani, G. Sotoudeh, Phytother. Res. 34 (2020) 896–903.

[33]J.-J. Yu, L.-B. Pei, Y. Zhang, Z.-Y. Wen, J.-L. Yang, J. Clin. Psychopharmacol. 35 (2015) 406–410.

[34]R. Steigerwalt, M. Nebbioso, G. Appendino, G. Belcaro, G. Ciammaichella, U. Cornelli, R. Luzzi, S. Togni, M. Dugall, M.R. Cesarone, E. Ippolito, B.M. Errichi, A. Ledda, M. Hosoi, M. Corsi, Panminerva Med. 54 (2012) 11–16.

[35]F. Mazzolani, S. Togni, Clin. Ophthalmol. 7 (2013) 939–945.

[36]F. Mazzolani, S. Togni, L. Giacomelli, R. Eggenhoffner, F. Franceschi, Eur. Rev. Med. Pharmacol. Sci. 22 (2018) 3617–3625.

[37]F. Mazzolani, Clin. Ophthalmol. 6 (2012) 801–806.

[38]S.-I. Park, E.H. Lee, S.R. Kim, Y.P. Jang, J. Pharm. Pharmacol. 69 (2017) 334–340.

[39]M.N.A. Mandal, J.M.R. Patlolla, L. Zheng, M.-P. Agbaga, J.-T.A. Tran, L. Wicker, A. Kasus-Jacobi, M.H. Elliott, C.V. Rao, R.E. Anderson, Free Radic. Biol. Med. 46 (2009) 672–679.

[40]C.B.M. Platania, A. Fidilio, F. Lazzara, C. Piazza, F. Geraci, G. Giurdanella, G.M. Leggio, S. Salomone, F. Drago, C. Bucolo, Front. Pharmacol. 9 (2018) 670.

[41]R.A. Kowluru, M. Kanwar, Nutr. Metab. 4 (2007) 8.

[42]W. Khimmaktong, H. Petpiboolthai, P. Sriya, V. Anupunpisit, J. Med. Assoc. Thai. 97 Suppl 2 (2014) S39–46.

[43]F. Pivari, A. Mingione, G. Piazzini, C. Ceccarani, E. Ottaviano, C. Brasacchio, M. Dei Cas, M. Vischi, M.G. Cozzolino, P. Fogagnolo, A. Riva, G. Petrangolini, L. Barrea, L. Di Renzo, E. Borghi, P. Signorelli, R. Paroni, L. Soldati, Nutrients 14 (2022).

[44]C.T. Peterson, A.R. Vaughn, V. Sharma, D. Chopra, P.J. Mills, S.N. Peterson, R.K. Sivamani, J Evid Based Integr Med 23 (2018) 2515690X18790725.

[45]R.-M.T. McFadden, C.B. Larmonier, K.W. Shehab, M. Midura-Kiela, R. Ramalingam, C.A. Harrison, D.G. Besselsen, J.H. Chase, J.G. Caporaso, C. Jobin, F.K. Ghishan, P.R. Kiela, Inflamm. Bowel Dis. 21 (2015) 2483–2494.

[46]Z.-Z. Sun, X.-Y. Li, S. Wang, L. Shen, H.-F. Ji, Appl. Microbiol. Biotechnol. 104 (2020) 3507–3515.

[47]X. Xu, H. Wang, D. Guo, X. Man, J. Liu, J. Li, C. Luo, M. Zhang, L. Zhen, X. Liu, Ren. Fail. 43 (2021) 1063–1075.

[48]Z. Zhang, Y. Chen, L. Xiang, Z. Wang, G.G. Xiao, J. Hu, Nutrients 9 (2017).

[49]S. Chashmniam, S.R. Mirhafez, M. Dehabeh, M. Hariri, M. Azimi Nezhad, B.F. Nobakht M Gh, Eur. J. Clin. Nutr. 73 (2019) 1224–1235.

[50]J. Wang, S.S. Ghosh, S. Ghosh, Am. J. Physiol. Cell Physiol. 312 (2017) C438–C445.

[51]J.-H. Li, T.-T. Wei, L. Guo, J.-H. Cao, Y.-K. Feng, S.-N. Guo, G.-H. Liu, Y. Ding, Y.-R. Chai, Naunyn. Schmiedebergs. Arch. Pharmacol. 394 (2021) 411–420.

[52]J. Deng, P. Ouyang, W. Li, L. Zhong, C. Gu, L. Shen, S. Cao, L. Yin, Z. Ren, Z. Zuo, J. Deng, Q. Yan, S. Yu, Int. J. Mol. Sci. 22 (2021).

[53]S. Pirmoradi, E. Fathi, R. Farahzadi, Y. Pilehvar-Soltanahmadi, N. Zarghami, Drug Res. 68 (2018) 213–221.

[54]H. Cherif, D.G. Bisson, P. Jarzem, M. Weber, J.A. Ouellet, L. Haglund, J. Clin. Med. Res. 8 (2019).

[55]M.J. Yousefzadeh, Y. Zhu, S.J. McGowan, L. Angelini, H. Fuhrmann-Stroissnigg, M. Xu, Y.Y. Ling, K.I. Melos, T. Pirtskhalava, C.L. Inman, C. McGuckian, E.A. Wade, J.I. Kato, D. Grassi, M. Wentworth, C.E. Burd, E.A. Arriaga, W.L. Ladiges, T. Tchkonia, J.L. Kirkland, P.D. Robbins, L.J. Niedernhofer, EBioMedicine 36 (2018) 18–28.

[56]Y. Zhang, X.-Y. Lin, J.-H. Zhang, Z.-L. Xie, H. Deng, Y.-F. Huang, X.-H. Huang, Oncol. Lett. 17 (2019) 127–134.

[57]C. Sun, S. Zhang, C. Liu, X. Liu, Cancer Biother. Radiopharm. 34 (2019) 634–641.

[58]S. Kuttikrishnan, K.S. Siveen, K.S. Prabhu, A.Q. Khan, E.I. Ahmed, S. Akhtar, T.A. Ali, M. Merhi, S. Dermime, M. Steinhoff, S. Uddin, Front. Oncol. 9 (2019) 484.

[59]X. Xu, Y. Zhu, Am. J. Transl. Res. 9 (2017) 3633–3641.

[60]E.T. Quispe-Soto, G.M. Calaf, Int. J. Oncol. 49 (2016) 2569–2577.

[61]M. Ono, T. Higuchi, M. Takeshima, C. Chen, S. Nakano, Biochem. Biophys. Res. Commun. 436 (2013) 186–191.

[62]M. Shakibaei, A. Mobasheri, C. Lueders, F. Busch, P. Shayan, A. Goel, PLoS One 8 (2013) e57218.

[63]M.A. Khan, S. Gahlot, S. Majumdar, Mol. Cancer Ther. 11 (2012) 1873–1883.

[64]S.J. Lee, C. Krauthauser, V. Maduskuie, P.T. Fawcett, J.M. Olson, S.A. Rajasekaran, BMC Cancer 11 (2011) 144.

[65]Y. Chen, W. Shu, W. Chen, Q. Wu, H. Liu, G. Cui, Basic Clin. Pharmacol. Toxicol. 101 (2007) 427–433.

[66]E. Mutlu Altundağ, A.M. Yılmaz, B.S. Serdar, A.T. Jannuzzi, S. Koçtürk, A.S. Yalçın, Nutr. Cancer 73 (2021) 703–712.

[67]N.S. Srivastava, R.A.K. Srivastava, Phytomedicine 52 (2019) 117–128.

[68]M.M. Abdel-Diam, D.H. Samak, Y.S. El-Sayed, L. Aleya, S. Alarifi, S. Alkahtani, Environ. Sci. Pollut. Res. Int. 26 (2019) 3659–3665.

[69]S. Kundur, A. Prayag, P. Selvakumar, H. Nguyen, L. McKee, C. Cruz, A. Srinivasan, S. Shoyele, A. Lakshmikuttyamma, J. Cell. Physiol. 234 (2019) 11103–11118.

[70]E. Mutlu Altundağ, A.M. Yılmaz, S. Koçtürk, Y. Taga, A.S. Yalçın, Nutr. Cancer 70 (2018) 97–108.

[71]G.H. Heeba, M.E. Mahmoud, A.A. El Hanafy, Toxicol. Ind. Health 30 (2014) 551–560.

[72]L. Zhang, X. Wang, L. Zhang, C. Virgous, H. Si, J. Nutr. Biochem. 73 (2019) 108222.

[73]A. Montgomery, T. Adeyeni, K. San, R.M. Heuertz, U.R. Ezekiel, J. Cancer 7 (2016) 1250–1257.

[74]V. Alfonso-Moreno, A. López-Serrano, E. Moreno-Osset, Rev. Esp. Enferm. Dig. 109 (2017) 875.

[75]S. Dalimi-Asl, H. Babaahmadi-Rezaei, G. Mohammadzadeh, Iran. J. Med. Sci. 45 (2020) 477–484.

[76]S.O. Ali, H.A. Darwish, N.A. Ismail, Basic Clin. Pharmacol. Toxicol. 118 (2016) 369–380.

[77]M. Nasiri, N. Zarghami, K.N. Koshki, M. Mollazadeh, M.P. Moghaddam, M.R. Yamchi, R.J. Esfahlan, A. Barkhordari, A. Alibakhshi, Asian Pac. J. Cancer Prev. 14 (2013) 3449–3453.

[78]N. Abdel-Magied, A.A. Elkady, Exp. Mol. Pathol. 111 (2019) 104299.

[79]H. Avci, E.T. Epikmen, E. Ipek, R. Tunca, S.S. Birincioglu, H. Akşit, S. Sekkin, A.N. Akkoç, M. Boyacioglu, Exp. Toxicol. Pathol. 69 (2017) 317–327.

[80]P. Mohapatra, S.R. Satapathy, S. Siddharth, D. Das, A. Nayak, C.N. Kundu, Int. J. Biochem. Cell Biol. 66 (2015) 75–84.