KSM-66 Ashwagandha®​ (​Withania somnifera​) Root Extract

TOP BENEFITS OF KSM-66 ASHWAGANDHA^®

Supports sleep*

Supports healthy stress resistance*

Supports cognitive performance*

WHAT IS KSM-66 ASHWAGANDHA^® 

KSM-66 Ashwagandha^® is a full-spectrum ashwagandha root extract. Ashwagandha (i.e., Indian ginseng) is a Rasayana—the category of elixirs and tonic herbs prized by the branch of Ayurvedic medicine concerned with rejuvenation and focused on promoting a youthful state of physical and mental health. Ashwagandha holds a prominent place among the Rasayana herbs, where it was used for many reasons including as general tonic and to infuse energy and vigor in circumstances characterized by exhaustion or a lack of physical energy. A key attribute is that ashwagandha promotes balance. As the English name Indian ginseng implies, ashwagandha was believed to share some of the attributes of ginseng, in essence supporting multiple areas of health and well-being, especially under conditions characterized by increased stress. Herbs that produce these types of nonspecific resistance to and recovery from stress—and which typically also support general well-being, healthy energy, and homeostasis—are called adaptogens. Among its studied benefits, ashwagandha supports sleep quality, relaxation, muscle recovery, cognitive function, immunity and a healthier stress response.*

NEUROHACKER’S KSM-66 ASHWAGANDHA^® SOURCING

KSM-66 Ashwagandha® was the product of 14 years of R&D. It is the most researched brand of ashwagandha, with a research focus on what happens in healthy people when they take the ingredient.

Created by Ixoreal Biomed Inc., the world's ashwagandha experts. Ixoreal owns the entire production chain from farm to the finished ingredient, allowing them to deliver high-quality ashwagandha with batch-to-batch consistency.

KSM-66 Ashwagandha^® is a “full-spectrum” root extract, which means it is designed to maintain the balance of the various constituents found in the root. It is standardized for ≥5% withanolides and <0.1% withaferin A.

KSM-66 Ashwagandha^® has won awards as an innovative ingredient and for sports nutrition. It has also qualified for an extensive number of certifications including Organic, Non-GMO, GRAS, Vegan and Gluten-Free.

KSM-66 Ashwagandha® is a registered trademark of Ixoreal Biomed Inc.

KSM-66 ASHWAGANDHA^® FORMULATING PRINCIPLES AND RATIONALE

We consider Withania somnifera (i.e., ashwagandha) to be an herbal adaptogen, so expect it to follow hormetic dosing principles. Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. Based on studies where different doses have been given in the same study, we also consider ashwagandha dosing to be somewhat akin to the Pareto Principle (i.e., 80-20 rule), because much of the benefits have occurred at a lower dose, and relatively modest additional gains are achieved at doses two- to four-fold higher (see Neurohacker Dosing Principles). Because of both of these reasons, it’s important to identify the lowest dose that can produce many of the desired responses when using ashwagandha. Since we also use ashwagandha in more than one product, it’s also important to us to ensure that a user taking several of our products will not inadvertently take too much ashwagandha. The most common dose of KSM-66 Ashwagandha^® in human studies has been 300 mg taken twice a day (i.e., 600 mg a day total). We consider this to be the upper end of the total amount of daily ashwagandha that we’d want a customer to take over a long period of time, and 300 mg to be the maximum at a given time of day (i.e., if being taken at dinner as an example). We consider the lower end of the beneficial range to be about 125-150 mg depending on the ashwagandha extract being used.*

WITHANIA SOMNIFERA KEY MECHANISMS

Promotes healthy sleep*

Supports sleep onset and total sleep time* [1,2]

Supports sleep efficiency* [1]

Supports quality of sleep* [1,3]

Supports slow wave sleep* [2]

Supports healthy mood and stress response*

Supports a calm mood* [1,4,5]

Supports healthy stress responses* [6–8]

Supports healthy stress hormone levels* [4,6–8]

Supports brain function*

Supports cognitive performance* [9–11]

Supports GABA signaling* [2,12–15]

Supports dopamine signaling* [16]

Influences acetylcholinesterase activity* [16]

Supports neuroprotective functions* [16–19]

Influences neural immune signaling* [5,19]

Supports healthy immune system function*

Supports innate immunity* [20–24]

Supports adaptive immunity* [20,21,24–33]

Supports immune system communication* [24,34–36]

Supports healthy immune signaling* [5,37,38]

Supports mitochondrial structure and function*

Supports mitochondrial function and structure [18,39]

Supports electron transport chain activity [16–18,40]

Supports citric acid cycle enzymes [40]

Promotes exercise performance*

Supports endurance performance* [41,42]

Supports muscle strength* [3,43]

Supports post-exercise recovery* [43]

Supports healthy metabolism*

Supports healthy blood glucose levels* [37,38,44–48]

Supports healthy leptin signaling* [5,47]

Supports healthy feeding behaviors* [5,6]

Supports lean mass* [43]

Enhances antioxidant defenses*

Supports antioxidant defenses* [16–18,48,49]

Replenishes glutathione (GSH) levels* [16,18,48]

Counters ROS levels and oxidative stress* [16,18,19,39]

Supports healthy thyroid function*

Supports thyroid function* [50–52]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]D. Langade, S. Kanchi, J. Salve, K. Debnath, D. Ambegaokar, Cureus 11 (2019) e5797.

[2]A. Kumar, H. Kalonia, Indian J. Pharm. Sci. 70 (2008) 806–810.

[3]A.A. Raut, N.N. Rege, F.M. Tadvi, P.V. Solanki, K.R. Kene, S.G. Shirolkar, S.N. Pandey, R.A. Vaidya, A.B. Vaidya, J. Ayurveda Integr. Med. 3 (2012) 111–114.

[4]A. Remenapp, K. Coyle, T. Orange, T. Lynch, D. Hooper, S. Hooper, K. Conway, H.A. Hausenblas, J. Ayurveda Integr. Med. 13 (2021) 100510.

[5]T. Kaur, G. Kaur, J. Neuroinflammation 14 (2017) 201.

[6]D. Choudhary, S. Bhattacharyya, K. Joshi, J. Evid. Based Complementary Altern. Med. 22 (2017) 96–106.

[7]K. Chandrasekhar, J. Kapoor, S. Anishetty, Indian J. Psychol. Med. 34 (2012) 255–262.

[8]B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, Journal of American Nutraceutical Association 11 (2008) 50–56.

[9]U. Pingali, R. Pilli, N. Fatima, Pharmacognosy Res. 6 (2014) 12–18.

[10]K.N.R. Chengappa, C.R. Bowie, P.J. Schlicht, D. Fleet, J.S. Brar, R. Jindal, J. Clin. Psychiatry 74 (2013) 1076–1083.

[11]D. Choudhary, S. Bhattacharyya, S. Bose, J. Diet. Suppl. 14 (2017) 599–612.

[12]A.K. Mehta, P. Binkley, S.S. Gandhi, M.K. Ticku, Indian J. Med. Res. 94 (1991) 312–315.

[13]J.P. Bhattarai, S.A. Park, S.K. Han, Phytotherapy Research (2009).

[14]H. Yin, D.H. Cho, S.J. Park, S.K. Han, The American Journal of Chinese Medicine 41 (2013) 1043–1051.

[15]M. Candelario, E. Cuellar, J.M. Reyes-Ruiz, N. Darabedian, Z. Feimeng, R. Miledi, A. Russo-Neustadt, A. Limon, J. Ethnopharmacol. 171 (2015) 264–272.

[16]M.J. Manjunath, Muralidhara, J. Food Sci. Technol. 52 (2015) 1971–1981.

[17]P. Kumar, A. Kumar, J. Med. Food 12 (2009) 591–600.

[18]A. Sood, A. Mehrotra, D.K. Dhawan, R. Sandhir, Metab. Brain Dis. 33 (2018) 1261–1274.

[19]B.A. Akhoon, S. Pandey, S. Tiwari, R. Pandey, Exp. Gerontol. 78 (2016) 47–56.

[20]L. Davis, G. Kuttan, J. Exp. Clin. Cancer Res. 21 (2002) 585–590.

[21]J. Mikolai, A. Erlandsen, A. Murison, K.A. Brown, W.L. Gregory, P. Raman-Caplan, H.L. Zwickey, J. Altern. Complement. Med. 15 (2009) 423–430.

[22]J. Bhat, A. Damle, P.P. Vaishnav, R. Albers, M. Joshi, G. Banerjee, Phytother. Res. 24 (2010) 129–135.

[23]A. Barua, M.J. Bradaric, P. Bitterman, J.S. Abramowicz, S. Sharma, S. Basu, H. Lopez, J.M. Bahr, Am. J. Reprod. Immunol. 70 (2013) 538–550.

[24]F. Malik, A. Kumar, S. Bhushan, D.M. Mondhe, H.C. Pal, R. Sharma, A. Khajuria, S. Singh, G. Singh, A.K. Saxena, K.A. Suri, G.N. Qazi, J. Singh, Eur. J. Cancer 45 (2009) 1494–1509.

[25]L. Davis, G. Kuttan, J. Ethnopharmacol. 71 (2000) 193–200.

[26]M. Gautam, S.S. Diwanay, S. Gairola, Y.S. Shinde, S.S. Jadhav, B.K. Patwardhan, Int. Immunopharmacol. 4 (2004) 841–849.

[27]S. Bani, M. Gautam, F.A. Sheikh, B. Khan, N.K. Satti, K.A. Suri, G.N. Qazi, B. Patwardhan, J. Ethnopharmacol. 107 (2006) 107–115.

[28]F. Malik, J. Singh, A. Khajuria, K.A. Suri, N.K. Satti, S. Singh, M.K. Kaul, A. Kumar, A. Bhatia, G.N. Qazi, Life Sci. 80 (2007) 1525–1538.

[29]G. Muralikrishnan, A.K. Dinda, F. Shakeel, Immunol. Invest. 39 (2010) 688–698.

[30]K. Yamada, P. Hung, T.K. Park, P.J. Park, B.O. Lim, J. Ethnopharmacol. 137 (2011) 231–235.

[31]S.K. Latheef, K. Dhama, H.A. Samad, M.Y. Wani, M.A. Kumar, M. Palanivelu, Y.S. Malik, S.D. Singh, R. Singh, Virusdisease 28 (2017) 115–120.

[32]S.P. Maurya, B.K. Das, R. Singh, S. Tyagi, Clin. Immunol. 203 (2019) 122–124.

[33]R. Kumar, J. Rai, N.C. Kajal, P. Devi, Indian J. Tuberc. 65 (2018) 246–251.

[34]B. Khan, S.F. Ahmad, S. Bani, A. Kaul, K.A. Suri, N.K. Satti, M. Athar, G.N. Qazi, Int. Immunopharmacol. 6 (2006) 1394–1403.

[35]C.D.P. Tripathi, P.K. Kushawaha, R.S. Sangwan, C. Mandal, S. Misra-Bhattacharya, A. Dube, Phytomedicine 24 (2017) 87–95.

[36]T. Kaur, H. Singh, R. Mishra, S. Manchanda, M. Gupta, V. Saini, A. Sharma, G. Kaur, Mol. Cell. Biochem. 427 (2017) 91–101.

[37]M.R. Shahraki, Z. Samadi Noshahr, H. Ahmadvand, A. Nakhaie, J. Basic Clin. Physiol. Pharmacol. 27 (2016) 387–391.

[38]Z. Samadi Noshahr, M.R. Shahraki, H. Ahmadvand, D. Nourabadi, A. Nakhaei, Rep Biochem Mol Biol 3 (2015) 62–67.

[39]P. Parihar, R. Shetty, P. Ghafourifar, M.S. Parihar, Cell. Mol. Biol. 62 (2016) 73–83.

[40]P. Senthilnathan, R. Padmavathi, V. Magesh, D. Sakthisekaran, Life Sci. 78 (2006) 1010–1014.

[41]J.S. Sandhu, B. Shah, S. Shenoy, S. Chauhan, G.S. Lavekar, M.M. Padhi, Int. J. Ayurveda Res. 1 (2010) 144–149.

[42]B. Choudhary, A. Shetty, D.G. Langade, Ayu 36 (2015) 63–68.

[43]S. Wankhede, D. Langade, K. Joshi, S.R. Sinha, S. Bhattacharyya, J. Int. Soc. Sports Nutr. 12 (2015) 43.

[44]S. Durg, S. Bavage, S.B. Shivaram, Phytother. Res. 34 (2020) 1041–1059.

[45]B. Andallu, B. Radhika, Indian J. Exp. Biol. 38 (2000) 607–609.

[46]T. Anwer, M. Sharma, K.K. Pillai, M. Iqbal, Basic Clin. Pharmacol. Toxicol. 102 (2008) 498–503.

[47]J. Lee, J. Liu, X. Feng, M.A. Salazar Hernández, P. Mucka, D. Ibi, J.W. Choi, U. Ozcan, Nat. Med. 22 (2016) 1023–1032.

[48]T. Anwer, M. Sharma, K.K. Pillai, G. Khan, Acta Pol. Pharm. 69 (2012) 1095–1101.

[49]S.K. Gupta, A. Dua, B.P.S. Vohra, Drug Metabol. Drug Interact. 19 (2003) 211–222.

[50]A.K. Sharma, I. Basu, S. Singh, J. Altern. Complement. Med. 24 (2018) 243–248.

[51]J.M. Gannon, P.E. Forrest, K.N. Roy Chengappa, J. Ayurveda Integr. Med. 5 (2014) 241–245.

[52]R. Jatwa, A. Kar, Phytother. Res. 23 (2009) 1140–1145.