What follows is a transcript of Dr. Dan Pardi and Neurohacker Co-founder, Daniel Schmachtenberger, discuss the surprising truths associated with the sleep patterns of hunter-gatherers and what that means for sleep quality in our modern era. 

What follows is a transcript from our discussion with Dan Pardi, sleep researcher at Stanford and Leiden University and CEO of humanOS.me, where we unpack the exact science of deep sleep. And even better, how to get more of it.

Everything you need to know about red light therapy's benefits, side effects, and protocols for using photobiomodulation at home.

Dr. Steven Gundry is a medical doctor, clinician, researcher, and a well-known author who has spent the last two decades studying the microbiome and helps patients use diet and nutrition as a key form of treatment. He retired as one of the world’s top cardiothoracic surgeons to teach patients how to eat, guiding them on how to get ahead of the problem, not fixing it after the fact.

Dr. Heather Sandison is joined by women’s health expert, visionary health pioneer, wellness speaker, and New York Times Best-Selling author, Dr. Christiane Northrup. We dive into women’s health and how to balance female hormones. 

We are joined by the innovator behind the Grounding Movement and CEO of Earth FX Inc., Clint Ober. He is known for the Earthing movie and the author of Earthing: The Most Important Health Discovery Ever. We dive into the benefits of grounding and how it can help the body relieve inflammation. We go over science around grounding the tools we can use to help us ground effectively. 

There is so much advice on longevity and aging that it can be hard to sort through all of the information. In this podcast transcript we dive into the science-backed approaches for living a longer and healthier life. Valter Longo, Ph.D., has thirty years of experience in longevity and healthy eating, and is one of the world’s experts in the field.

In 1958, Jack Preiss and Philip Handler published a scientific paper describing how NAD⁺ was made from niacin in three steps.(1) This pathway was later named the Preiss-Handler pathway after the co-discoverers. It describes the enzyme steps needed to convert niacin into the NAD⁺ molecule.

The salvage pathway is used to produce NAD⁺ from nicotinamide molecules. Whether the source of the nicotinamide is vitamin B3 (as niacinamide), newer nicotinamides (e.g., nicotinamide riboside [NR], nicotinamide mononucleotide [NMN]), or molecules in food that get broken down during digestion into nicotinamide, the salvage pathway turns them into NAD⁺ in our tissues.

Most organisms have several alternatives for producing the NAD⁺ molecule. In humans, there are three major NAD⁺ biosynthesis pathways: the De Novo Pathway, starting from the essential amino acid L-tryptophan; the Preiss-Handler pathway, using niacin (nicotinic acid); and the Salvage Pathway from niacinamide (nicotinamide). In this article, we’ll be covering the De Novo Pathway.

In Silicon Valley, the hub of anti-aging research and funding, countless entrepreneurs and high-profile celebrities use fasting to combat the effects of aging. In Anti-Aging Benefits of Fasting, we will explore the mechanisms that create these fasting benefits. This part is more scientific than the others, but we emphasize only crucial components in an easily digestible format.