Aloe Vera Inner Leaf Juice Powder

TOP BENEFITS OF ALOE VERA

Supports skin health * 

Supports healthy metabolism *

WHAT IS ALOE VERA?

Aloe vera (synonym: Aloe barbadensis) is a succulent plant of the genus Aloe. It grows wild in tropical, semi-tropical, and arid climates around the world. Aloe vera has been used in various traditional healing systems (Ayurveda, Chinese, Egyptian, Greek, Roman, etc.) with its use dating back several thousand years. The fleshy leaves are filled with a clear gel (this is what’s used to make the juice) that contains hundreds of bioactive compounds responsible for the multifunctional activity of Aloe, including polysaccharides, vitamins, enzymes, minerals, and phenolic compounds. In addition to water, aloe polysaccharides are the main compounds of the gel, Aloe vera also contains many antioxidant compounds, including α-tocopherol (vitamin E), ascorbic acid (vitamin C), carotenoids, flavonoids and tannins. Modern uses of oral Aloe vera largely revolve around supporting skin, digestive, immune, and metabolic health [1,2].* 

NEUROHACKER’S ALOE VERA SOURCING

Aloe Vera Inner Leaf Juice Powder is made from organically grown aloe and prepared through a proprietary process that retains more of the natural elements found in fresh aloe than standard freeze-dried Aloe Vera powder. 

Aloe Vera Inner Leaf Juice Powder is a 200X concentrate: it takes 200 grams of Aloe Vera leaf juice to make 1 gram of the powder.

Aloe Vera Inner Leaf Juice Powder is supplied by Terry Laboratories, a worldwide leader in producing high quality and pure Aloe Vera extracts since 1973.

Aloe Vera Inner Leaf Juice Powder has been certified by the International Aloe Science Council (IASC). IASC certification ensures products contain Aloe vera of the highest quality and purity, and are tested and controlled for aloin content.

Aloe Vera Inner Leaf Juice Powder is non-GMO, gluten-free, vegan, organic, and fair trade certified.

ALOE VERA FORMULATING PRINCIPLES AND RATIONALE

Because studies have used different types of Aloe vera—juice, gel, concentrates, etc.—there’s no standard serving that applies to aloe independent of the type being used. The organic inner leaf juice powder we use is a 200X concentrate, which means that it takes 200 grams of Aloe vera inner leaf juice to make 1 gram of the powder. If it were reconstituted with water, a 300 mg serving would be the equivalent of drinking a bit more than 2 ounces of Aloe vera juice. One of our dosing principles is to determine whether there is a dosing range in which many of the benefits occur and above which there appears to be diminishing returns (see Neurohacker Dosing Principles). We consider Aloe vera to be one of these compounds where more isn’t necessarily better, because, for example, in a human study where two serving were compared, the lower serving resulted in superior skin function and appearance responses [3].*

ALOE VERA KEY MECHANISMS

Supports skin health*

May help minimize the appearance of fine lines and wrinkles* [3–6]

Supports skin elasticity* [3,7–9] 

Supports skin hydration* [4–7]

Supports healthy transepidermal water loss (TEWL) levels* [5,7]

Supports dermal extracellular matrix (ECM) structure (collagen, hyaluronic acid)* [3–7,9–14]

Supports nail structure and health* [5]

Supports skin in adapting to environmental stress* [6,9,15]

Supports Nrf-2 signaling and antioxidant defenses* [16]

Supports healthy immune/cytokine signaling* [6]

Supports skin growth factor production (TGF-β1, EGF, bFGF, IGF-1, VEGF)* [10,13,14]

Supports skin vascularity* [10]

Supports injury repair functions* [13]

Promotes healthy metabolic function*

Supports maintenance of healthy blood glucose levels* [17–19]

Supports maintenance of healthy blood lipid levels* [17–19]

Supports healthy body fat levels* [20]

Supports antioxidant defenses*

Supports antioxidant defenses* [21–23]

Counters ROS production and oxidative stress* [21–24]

Supports free radical scavenging* [24,25]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]S.K. Kar, T.K. Bera, International Journal of Pharmaceutical Sciences and Research 9 (2018) 1416–1423.

[2]M.H. Radha, N.P. Laxmipriya, Afr. J. Tradit. Complement. Altern. Med. 5 (2015) 21–26.

[3]S. Cho, S. Lee, M.-J. Lee, D.H. Lee, C.-H. Won, S.M. Kim, J.H. Chung, Ann. Dermatol. 21 (2009) 6–11.

[4]M. Tanaka, E. Misawa, K. Yamauchi, F. Abe, C. Ishizaki, Clin. Cosmet. Investig. Dermatol. 8 (2015) 95–104.

[5]C. Kaminaka, Y. Yamamoto, M. Sakata, C. Hamamoto, E. Misawa, K. Nabeshima, M. Saito, M. Tanaka, F. Abe, M. Jinnin, J. Dermatol. 47 (2020) 998–1006.

[6]E. Misawa, M. Tanaka, M. Saito, K. Nabeshima, R. Yao, K. Yamauchi, F. Abe, Y. Yamamoto, F. Furukawa, Photodermatol. Photoimmunol. Photomed. 33 (2017) 101–111.

[7]M. Tanaka, Y. Yamamoto, E. Misawa, K. Nabeshima, M. Saito, K. Yamauchi, F. Abe, F. Furukawa, Skin Pharmacol. Physiol. 29 (2016) 309–317.

[8]M. Tanaka, Y. Yamamoto, E. Misawa, K. Nabeshima, M. Saito, K. Yamauchi, F. Abe, F. Furukawa, Clin. Cosmet. Investig. Dermatol. 9 (2016) 435–442.

[9]M. Saito, M. Tanaka, E. Misawa, R. Yao, K. Nabeshima, K. Yamauchi, F. Abe, Y. Yamamoto, F. Furukawa, Biosci. Biotechnol. Biochem. 80 (2016) 1416–1424.

[10]A. Atiba, M. Nishimura, S. Kakinuma, T. Hiraoka, M. Goryo, Y. Shimada, H. Ueno, Y. Uzuka, Am. J. Surg. 201 (2011) 809–818.

[11]P. Chithra, G.B. Sajithlal, G. Chandrakasan, J. Ethnopharmacol. 59 (1998) 179–186.

[12]P. Chithra, G.B. Sajithlal, G. Chandrakasan, Mol. Cell. Biochem. 181 (1998) 71–76.

[13]F. Ali, N. Wajid, M.G. Sarwar, A.M. Qazi, Curr. Pharm. Biotechnol. (2020).

[14]R. Yao, M. Tanaka, E. Misawa, M. Saito, K. Nabeshima, K. Yamauchi, F. Abe, Y. Yamamoto, F. Furukawa, J. Food Sci. 81 (2016) H2849–H2857.

[15]D. Rodrigues, A.C. Viotto, R. Checchia, A. Gomide, D. Severino, R. Itri, M.S. Baptista, W.K. Martins, Photochem. Photobiol. Sci. 15 (2016) 334–350.

[16]L. Yuan, X. Duan, R. Zhang, Y. Zhang, M. Qu, J. Dermatolog. Treat. 31 (2020) 300–308.

[17]H.F. Huseini, S. Kianbakht, R. Hajiaghaee, F.H. Dabaghian, Planta Med. 78 (2012) 311–316.

[18]S. Devaraj, M. Yimam, L.A. Brownell, I. Jialal, S. Singh, Q. Jia, Metab. Syndr. Relat. Disord. 11 (2013) 35–40.

[19]S. Alinejad-Mofrad, M. Foadoddini, S.A. Saadatjoo, M. Shayesteh, J. Diabetes Metab. Disord. 14 (2015) 22.

[20]H.-C. Choi, S.-J. Kim, K.-Y. Son, B.-J. Oh, B.-L. Cho, Nutrition 29 (2013) 1110–1114.

[21]S. Rajasekaran, K. Sivagnanam, S. Subramanian, J. Pharm. Pharmacol. 57 (2005) 241–246.

[22]N. Klaikeaw, J. Wongphoom, D. Werawatganon, M. Chayanupatkul, P. Siriviriyakul, World J. Hepatol. 12 (2020) 363–377.

[23]M. Guven, U.H. Gölge, E. Aslan, M.H. Sehitoglu, A.B. Aras, T. Akman, M. Cosar, Biomed. Pharmacother. 79 (2016) 201–207.

[24]M.-C. Kang, S.Y. Kim, Y.T. Kim, E.-A. Kim, S.-H. Lee, S.-C. Ko, W.A.J.P. Wijesinghe, K.W. Samarakoon, Y.-S. Kim, J.H. Cho, H.-S. Jang, Y.-J. Jeon, Carbohydr. Polym. 99 (2014) 365–371.

[25]A. López, M.S. de Tangil, O. Vega-Orellana, A.S. Ramírez, M. Rico, Molecules 18 (2013) 4942–4954.